Research Areas
- Infectious Diseases in Changing Environment
- Natural and anthropogenic disturbances in the environment bring about major ecological changes that can promote the transmission of pathogens. Some of the major infectious diseases that are becoming prominent due to environmental change are vector-borne diseases (e.g., dengue, malaria) and waterborne diseases (e.g., rotavirus, cholera, leptospirosis). We implement advanced methodological tools to measure the impact of environmental changes on the incidence of infectious diseases retrospectively or prospectively for the future. Generating such scientific evidence is crucial to support changes necessary to improve the healthcare system and disease control strategies.
- Luise Nathalie Nottmeyer, Ben Armstrong, Rachel Lowe, Sam Abbott, Sophie Meakin, Kathleen O’Reilly, Rosa Von Borries, Rochelle Schneider, Dominic Royé, Masahiro Hashizume, Mathilde Pascal, Aurelio Tobias, Ana Maria Vicedo-Cabrera, Eric Lavigne, Patricia Matus Correa, Nicolás Valdés Ortega, Jan Kynčl, Aleš Urban, Hans Orru, Niilo Ryti, Jouni Jaakkola, Marco Dallavalle, Alexandra Schneider, Yasushi Honda, Chris Fook Sheng Ng, Barrak Alahmad, Gabriel Carrasco, Iulian Horia Holobâc, Ho Kim, Whanhee Lee, Carmen Iñiguez, Michelle Bell, Antonella Zanobetti, Joel Schwartz, Noah Scovronick, Micheline de Sousa Zanotti Stagliorio Coélho, Paulo Hilario Nascimento Saldiva, Magali Hurtado Diaz, Antonio Gasparrini, Francesco Sera. The association of COVID-19 incidence with temperature, humidity, and UV radiation – A global multi-city analysis. Science of the Total Environment. 2023, 854: 158636.
- Chua PLC, Seposo XT, Hashizume M. Heat exposure and the transmission of infectious diseases. In: Guo Y, Li S, eds. Heat exposure and human health in the context of climate change. Amsterdam, the Netherlands, Oxford, United Kingdom, and Cambridge, USA. Elsevier. 2023: 189-221.
- Michiko Toizumi, Chisei Satoh, Billy J Quilty, Hien Anh Thi Nguyen, Lina Madaniyazi, Lien Thuy Le, Chris Fook Sheng Ng, Minoru Hara, Chihiro Iwasaki, Mizuki Takegata, Noriko Kitamura, Monica Larissa Nation, Catherine Satzke, Hung Thai Do, Minh Xuan Bui, Kim Mulholland, Stefan Flasche, Duc Anh Dang, Ken-ichi Kaneko, and Lay-Myint Yoshida. Effect of Pneumococcal Conjugate Vaccine on Prevalence of Otitis Media with Effusion among Children in Vietnam. Vaccine. 2022, 40(36): 5366-5375.
- Khine Mya New, Mya Myat Ngwe Tun, Theingi Win Myat, Chris Fook Sheng Ng, Moh Moh Htun, Htin Lin, Nang Sarm Hom, Aung Min Soe, Annie Elong Ngono, Shinjiro Hamano, Kouichi Morita, Kyaw Zin Thant, Sujan Shresta, Hlaing Myat Thu, and Meng Ling Moi. Acute-Phase Serum Cytokine Levels and Correlation with Clinical Outcomes in Children and Adults with Primary and Secondary Dengue Virus Infection in Myanmar between 2017 and 2019. Pathogens. 2022, 11(5): 558.
- Ikkoh Yasuda, Motoi Suzuki, Haruka Maeda, Mayumi Terada, Eiichiro Sando, Chris Fook Sheng Ng, Lay-Myint Yoshida, Konisuke Morimoto. Respiratory virus detection in the upper respiratory tract of asymptomatic, community-dwelling older people. BMC Infectious Diseases. 2022, 22: 411.
- Paul LC Chua, Chris Fook Sheng Ng, Aurelio Tobias, Xerxes Seposo, Masahiro Hashizume. Associations between ambient temperature and enteric infections by pathogen: a systematic review and meta-analysis. Lancet Planetary Health. 2022; 6(3): e202-e218.
- Daisuke Onozuka, Yuta Tanoue, Shuhei Nomura, Takayuki Kawashima, Daisuke Yoneoka, Akifumi Eguchi, Chris Fook Sheng Ng, Kentaro Matsuura, Shoi Shi, Koji Makiyama, Shinya Uryu, Yumi Kawamura, Shinichi Takayanagi, Stuart Gilmour, Takehiko I. Hayashi, Hiroaki Miyata, Francesco Sera, Tomimasa Sunagawa, Takuri Takahashi, Yuuki Tsuchihashi, Yusuke Kobayashi, Yuzo Arima, Kazuhiko Kanou, Motoi Suzuki, Masahiro Hashizume. Reduced mortality during the COVID-19 outbreak in Japan, 2020: a two-stage interrupted time-series design. International Journal of Epidemiology. 2022; 51(1): 75-84.
- Chua PLC, Ng CFS, Tobias A, Seposo XT, Hashizume M. Associations between ambient temperature and enteric infections by pathogen: a systematic review and meta-analysis. The Lancet Planetary Health. 2022; 6(3): e202-e218. doi:10.1016/S2542-5196(22)00003-1
- Chua PLC, Ng CFS, Madaniyazi L, Seposo X, Salazar MA, Huber V, Hashizume M. Projecting temperature-attributable mortality and hospital admissions due to enteric infections in the Philippines. Environmental Health Perspectives. 2022; 130(2): 027011. doi:10.1289/EHP9324
- Chua PLC, Ng CFS, Tobias A, Seposo XT, Hashizume M.. Associations between ambient temperature and enteric infections by pathogen: a systematic review and meta-analysis. Lancet Planet Health. 2022;6(3):e202-e218. doi: 10.1016/S2542-5196(22)00003-1.
- Xerxes Tesoro Seposo, Lina Madaniyazi, Chris Fook Sheng Ng, Masahiro Hashizume, Yasushi Honda. COVID-19 pandemic modifies temperature and heat-related illness ambulance transport association in Japan: A nationwide observational study. Environmental Health. 2021; 20: 122.
- Ikkoh Yasuda, Nobuo Saito, Motoi Suzuki, Edmundo B. Lopez, Jose Benito Villarama, Eumelia P. Salva, Elizabeth Freda O. Telan, Dorcas Valencia Umipig, Rontgene M. Solante, Ferdinand De Guzman, Maricel R. Ribo, Ana Ria Sayo, Jezreel Lazaro, Michio Yasunamia, Nobuo Koizumi, Emi Kitashoja, Kentaro Sakashita, Shingo Inoue, Chris Fook Sheng Ng, Chris Smith, Christopher M. Parry, Koya Ariyoshi. Unique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients. PLOS ONE. 2021; 16(11): e0258936.
- Francesco Sera, Ben Armstrong, Sam Abbott, Sophie Meakin, Kathleen O’Reilly, Rosa von Borries, Rochelle Schneider, Dominic Royé, Masahiro Hashizume, Mathilde Pascal, Aurelio Tobias, Ana Maria Vicedo-Cabrera, MCC Collaborative Research Network*, CMMID COVID-19 working group, Antonio Gasparrini, Rachel Lowe. (* includes Chris Fook Sheng Ng, who contributed to data collection and manuscript preparation) Potential drivers of COVID-19 seasonality in 409 cities across 26 countries. Nature Communications. 2021; 12: 5968.
- Lina Madaniyazi, Xerxes Seposo, Chris Fook Sheng Ng, Aurelio Tobias, Michiko Toizumi, Hiroyuki Moriuchi, Lay-Myint Yoshida, Masahiro Hashizume. Respiratory syncytial virus outbreaks are predicted after the COVID-19 pandemic in Tokyo, Japan. Japanese Journal of Infectious Diseases. 2021; online ahead of print.
- Paul LC Chua, Chris Fook Sheng Ng, Adovich Rivera, Eumelia Salva, Miguel Antonio Salazar, Veronika Huber, Masahiro Hashizume. Association between ambient temperature and severe diarrhoea in the National Capital Region, Philippines. International Journal of Environmental Research and Public Health. 2021; 18: 8191.
- Lina Madaniyazi, Chris Fook Sheng Ng, Xerxes Seposo, Michiko Toizumi, Lay Myint Yoshida, Yasuda Honda, Masahiro Hashizume. Role of temperature, influenza and other local characteristics in seasonality of mortality: a population-based time-series study in Japan. BMJ Open. 2021; 11: e044876.
- Xerxes Seposo, Chris Fook Sheng Ng, Lina Madaniyazi. Immediate and delayed meteorological effects on COVID-19 time-varying infectiousness in Tropical Cities. Atmosphere. 2021; 12: 513.
- Aurelio Tobias, Lina Madaniyazi, Chris Fook Sheng Ng, Xerxes Seposo, Masahiro Hashizume. Can SARS-CoV-2 global seasonality be determined after one year of pandemic? Environmental Epidemiology. 2021; 5: e146.
- Shinya Uryu, Yuta Tanoue, Shuhei Nomura, Kentara Matsuura, Koji Makiyama, Takayuki Kawashima, Daisuke Yoneoka, Akifumi Eguchi, Yumi Kawamura, Stuart Gilmour, Haruka Sakamoto, Kazuki Shimizu,Chris Fook Sheng Ng, Masahiro Hashizume. Trends in emergency transportation due to heat illness under the new normal lifestyle in the COVID-19 era, in Japan and 47 prefectures. Science of the Total Environment. 2021; 768: 144723.
- Chua PLC, Ng CFS, Rivera A, Salva E, Salazar MA, Huber V, Hashizume M. Association between ambient temperature and severe diarrhoea in the National Capital Region, Philippines. International Journal of Environmental Research and Public Health. 2021; 18(15): 8191. doi: 10.3390/ijerph18158191.
- Chua PLC, Huber V, Ng CFS, Seposo X, Madaniyazi L, Hales S, Woodward A, Hashizume M. Global projections of temperature-attributable mortality due to enteric infections. The Lancet Planetary Health. 2021; 5(7): e436-e445. doi: 10.1016/S2542-5196(21)00152-2.
- Chua PLC, Huber V, Ng CFS, Seposo XT, Madaniyazi L, Hales S, Woodward A, Hashizume M. Global projections of temperature-attributable mortality due to enteric infections: a modelling study. Lancet Planet Health. 2021;5(7):e436-e445. doi: 10.1016/S2542-5196(21)00152-2.
- Nomura S (co-first), Yoneoka D, Tanaka S, Ishizuka A, Peter U, Rauniyar SK, Nakamura K, Uneyama H, Hayashi N, Shibuya K. Prediction of disability-adjusted life years for diseases due to low fruit intake in 2017-2040 in Japan. Public Health Nutrition. 2021; 24(10): 3156-66.
- Takayuki Kawashima, Shuhei Nomura, Yuta Tanoue, Daisuke Yoneoka, Akifumi Eguchi, Chris Fook Sheng Ng, Kentaro Matsuura, Shoi Shi, Koji Makiyama, Shinya Uryu, Yumi Kawamura, Shinichi Takayanagi, Stuart Gilmour, Hiroaki Miyata, Tomimasa Sunagawa, Takuri Takahashi, Yuuki Tsuchihashi, Yusuke Kobayashi, Yuzo Arima, Kazuhiko Kanou, Motoi Suzuki, Masahiro Hashizume. Estimation of excess all-cause deaths during the COVID-19 pandemic in Japan and 47 prefectures, January to May 2020. Emerging Infectious Diseases. 2020; 27: 789-795.
- Chris Fook Sheng Ng, Xerxes T Seposo, Meng Ling Moi, Muhammad Abdul Basit Ahmad Tajudin, Lina Madaniyazi, Mazrura Sahani. Characteristics of COVID-19 epidemic and control measures to curb transmission in Malaysia. International Journal of Infectious Diseases. 2020; 101: 409-411.
- Nang Mon Hsai, Mitsuaki Matsui, Chris Fook Sheng Ng, Cho Thet Khaing, Imoto Atsuko, Ahmed M Sayed, Nguyen Tien Huy, Yasuhiko Kamiya, Kazuhiko Moji. Satisfaction of pregnant women with antenatal care services at Women and Children Hospital in South Okkalapa, Myanmar: a facility-based cross-sectional study triangulated with qualitative study. Patient Preference and Adherence. 2020; 14: 2489-2499.
- Co Thach Nguyen, Meng Ling Moi, Thi Quynh Mai Le, Thi Thu Thuy Nguyen, Thi Bich Hau Vu, Hai Tuan Nguyen, Thi Thu Hang Pham, Thi Hien Thu Le, Le Manh Hung Nguyen, Minh Huong Phu Ly, Chris Fook Sheng Ng, Taichiro Takemura, Kouchi Morita, Futoshi Hasebe. Prevalence of Zika virus neutralizing antibodies in healthy adults in Vietnam during and after the Zika virus epidemic season: a longitudinal population-based survey. BMC Infectious Diseases. 2020; 20(1): 332.
- Yoonhee Kim, J. Venkata Ratnam, Takeshi Doi, Yushi Morioka, Swadhin Behera, Ataru Tsuzuki, Noboru Minakawa, Neville Sweijd, Philip Kruger, Rajendra Maharaj, Chisato Imai, Chris Fook Sheng Ng, Yeonseung Chung. Malaria predictions based on seasonal climate forecasts in South Africa: A time series distributed lag nonlinear model. Scientific Reports. 2019; 9(1):17882.
- Naohiko Matsushita, Yoonhee Kim, Chris Fook Sheng Ng, Masao Moriyama, Tamotsu Igarashi, Kazuhida Yamamoto, Wellington Otieno, Noboru Minakawa, Masahiro Hashizume. Differences of rainfall-malaria associations in lowland and highland in Western Kenya. International Journal of Environmental Research and Public Health. 2019; 16(19): 3693.
- Naohiko Matsushita, Chris Fook Sheng Ng, Yoonhee Kim, Motoi Suzuki, Nobuo Saito, Koya Ariyoshi, Eumelia P. Salva, Efren M. Dimaano, Jose B. Villarama, Winston S. Go, Masahiro Hashizume. The non-linear and lagged short-term relationship between rainfall and leptospirosis and the intermediate role of floods in the Philippines. PLOS Neglected Tropical Diseases. 2018; 12(4): e0006331.
- Lam HY, Rivera AS, Chua PLC, Lopez JF, Cheng KG, Palasi WA. Cost of hospitalization of different types of schistosomiasis cases in endemic areas in the Philippines: indicating the need to increase the coverage of government health insurance. Acta Medica Philippina. 2018; 52(2):140-146. doi:10.47895/amp.v52i2.421.
- Belizario VY Jr, Totañes FG, Chua PLC. Preventive chemotherapy. In: Belizario VY Jr, de Leon WU, eds. Medical Parasitology in the Philippines. Quezon City, Philippines: University of the Philippines Press. 2015. 410-417.
- Belizario VY Jr, Erfe JM, Naig JA, Chua PLC. Evidence of increasing risk of schistosomiasis among school-age children in the municipality of Calatrava, Province of Negros Occidental, Philippines. Asian Pacific Journal of Tropical Medicine. 2015;8(5):373-377. doi:10.1016/S1995-7645(14)60346-1.
- Belizario VY Jr, Marfori RM, Chua PLC, Naig JA, Erfe JM. School-based combined mass drug administration for soil-transmitted helminthiases and schistosomiasis among school-age children: lessons from two co-endemic areas in the Philippines. Asian Pacific Journal of Tropical Disease. 2015;5(5):358-362. doi: https://doi.org/10.1016/S2222-1808(14)60797-0.
- Belizario VY Jr, Liwanag HC, Naig JA, Chua PLC, Madamba MI, Dahildahil RO. Parasitological and nutritional status of school-age and preschool-age children in four villages in Southern Leyte, Philippines: Lessons for monitoring the outcome of Community-Led Total Sanitation. Acta Tropica. 2014;141PA:16-24. doi: 10.1016/j.actatropica.2014.09.008.
- Belizario VY Jr, Chua PLC, Liwanag HC, Naig JA, Erfe JM. Soil-transmitted helminthiases in secondary school students in selected sites in two provinces in the Philippines: policy implications. Journal of Tropical Pediatrics. 2014;60(4):303-307. doi: 10.1093/tropej/fmu018.
- Sanza M, Totañes FG, Chua PLC, Belizario VY Jr. Monitoring the impact of a mebendazole mass drug administration initiative for soil-transmitted helminthiases (STH) control in the Western Visayas Region of the Philippines from 2007 through 2011. Acta Tropica. 2013;127(2):112-117. doi: 10.1016/j.actatropica.2013.03.017.
- Erfe JM, Belizario VY Jr., Chua PLC, Naig JR. Validating the WHO dose pole in the Philippines for school-based mass drug administration of praziquantel for morbidity control of schistosomiasis. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2013;107(10):615-619. doi: 10.1093/trstmh/trt076.
- Hashizume M, Faruque ASG, Dewan AM. Rainfall dependence of hospital visits of Aeromonas-positive diarrhoea in Dhaka. In AM Dewan and RJ Corner (Eds) Dhaka Megacity: Geospatial Perspecitives on Urbanization, Environment and Health, Springer Geography. 2013:333-344.
- Kim Y, Ratnam JV, Doi T, Morioka Y, Behera S, Tsuzuki A, Minakawa N, Sweijd N, Kruger P, Maharaj R, Imai CC, Ng CFN, Chung Y, Hashizume M. Malaria predictions based on seasonal climate forecasts in South Africa: A time series distributed lag nonlinear model. Scientific Reports. 2019;9(1):17882. doi:10.1038/s41598-019-53838-3.
- Onozuka D, Gasparrini A, Sera F, Hashizume M, Honda Y. Modeling future projections of temperature-related excess morbidity due to infectious gastroenteritis under climate change conditions in Japan. Environ Health Perspect. 2019;127(7):77006. doi: 10.1289/EHP4731.
- Matsushita N, Ng CFS, Kim Y, Suzuki M, Saito N, Ariyoshi K, Salva EP, Dimaano EM, Villarama JB, Go WS, Hashizume M. The non-linear and lagged short-term relationship between rainfall and leptospirosis and the intermediate role of floods in the Philippines. PLoS Negl Trop Dis. 2018;12(4)
- Imai C, Armstrong B, Chalabi Z, Mangtani P, Hashizume M. Time series regression model for infectious disease and weather. Environ Res. 2015;142:319-327.
- Imai C, Hashizume M. A Systematic review on methodology: time series regression analysis for environmental factors and infectious diseases. Trop Med Health. 2015;43(1):1-9.